doi: 10.3390/nu10040493. Vitamin D deficiency or insufficiency did not increase the risk of prostate cancer, and higher 25(OH)D concentrations were not associated with a lower risk. International Journal of Epidemiology 2019;48:1416-24. Women with 25(OH)D levels of less than 30 nmol/L (12 ng/mL) had a 43% higher MS risk than women with levels of 50 nmol/L (20 ng/mL) or higher. Vitamin D supplements and prevention of cancer and cardiovascular disease. [, Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, et al. Vitamin D- fortified. However, because the extent and frequency of sunscreen use are unknown, the role that sunscreen may play in reducing vitamin D synthesis is unclear [1]. A few studies have examined the effect of vitamin D supplementation on specific cancers. UVB radiation does not penetrate glass, so exposure to sunshine indoors through a window does not produce vitamin D [27]. [, Heath AK, Hodge AM, Ebeling PR, Eyles DW, Kvaskoff D, Buchanan DD, et al. At baseline, participants had an adequate mean serum 25(OH)D level of 60 nmol/L (24 ng/mL). In addition, the USPSTF recommended against supplementation with 10 mcg (400 IU) or less of vitamin D and 1,000 mg or less of calcium to prevent fractures in this population, but it could not determine the balance of benefits and harms from higher doses. Statin medications reduce cholesterol synthesis. [, Zhang R, Li B, Gao X, Tian R, Pan Y, Jiang Y, et al. C4Yourself is an online platform for efficient and transparent management of your tutoring data. One study, for example, tested 25(OH)D levels in 1,092 women in Finland an average of 9 years before their MS diagnosis and compared their outcomes with those of 2,123 similar women who did not develop MS [139]. A review of 71 observational studies in adults with and without type 2 diabetes from 16 countries found a significant inverse relationship between vitamin D status and blood sugar levels in participants who did and did not have diabetes [146]. Office of Dietary Supplements, National Institutes of Health. Vitamin D supplementation and prevention of type 2 diabetes. The AAP also recommends 10 mcg (400 IU)/day supplemental vitamin D for all infants who are not breastfed and ingest less than 1,000 mL/day vitamin D-fortified formula or milk. Cancer Res 2006;66:10213-9. Vitamin D helps regulate the renin-angiotensin-aldosterone system (and thereby blood pressure), vascular cell growth, and inflammatory and fibrotic pathways [118]. However, the incidence of rickets is increasing globally, even in the United States and Europe, especially among immigrants from African, Middle-Eastern, and Asian countries [51]. Pediatr Clin North Am 2001;48:53-67. Summary. In contrast to water-soluble vitamins, the body has no easy way of getting rid of fat-soluble vitamins. [, Taylor CL, Patterson KY, Roseland JM, Wise SA, Merkel JM, Pehrsson PR, Yetley EA. Role of vitamin D in atherosclerosis. In this procedure, part of the upper small intestine, where vitamin D is absorbed, is bypassed, and vitamin D that is mobilized into the bloodstream from fat stores might not raise 25(OH)D to adequate levels over time [66,67]. [. The AAP recommends 10 mcg (400 IU)/day vitamin D supplements for exclusively and partially breastfed infants starting shortly after birth and lasting until they are weaned and consume at least 1,000 mL/day vitamin D-fortified formula or whole milk [57]. Nutrients 2018; 10, 375; doi:10.3390/nu10030375 [, Mousa A, Naderpoor N, Teede H, Scragg R, de Courten, B. Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Journal of Nutrition Science 2018;7:1-7. Lancet Diabetes-Endocrinol 2014;2:719-29. Some studies have used dietary supplements containing the 25(OH)D3 form of vitamin D. Per equivalent microgram dose, 25(OH)D3 is three to five times as potent as vitamin D3 [37,38]. [, Robien K, Oppeneer SJ, Kelly JA, Hamilton-Reeves JM. [, Taylor CL, Roseland JM, Coates PM, Pehrsson PR. Vitamin D supplementation did not lower the risk of total fractures, hip fractures, or nonvertebral fractures as compared with placebo. [, Yin L, Ordonez-Mena JM, Chen T, Schottker B, Arndt V, Brenner H. Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis. In fact, up to 40% of U.S. adults are considered to have insufficient levels (not enough) of vitamin D, while around 6% are considered deficient in. The products you buy from Cforyourself are the same price as if you had bought them directly from Nutribiotic. products like plain whole cow's milk (for children 12 months and older), yogurt, cereals, and some 100% juices. August 12, 2022 Supplemental vitamin D and incident fractures in midlife and older adults. No association between vitamin D supplementation and risk of colorectal adenomas or serrated polyps in a randomized trial. Increasing incidence of nutritional rickets: A population-based study in Olmsted County, Minnesota. Calcium plus vitamin D supplementation and the risk of fractures. [, Moyer VA. Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive Services Task Force recommendation statement. Mayo Clin Proc 2013;88:720-55. Type B UV (UVB) radiation with a wavelength of approximately 290320 nanometers penetrates uncovered skin and converts cutaneous 7-dehydrocholesterol to previtamin D3, which in turn becomes vitamin D3. Public Health Nutrition 2020;23:1153-64. However, the evidence on the impact of vitamin D and calcium supplements on fractures in community-dwelling individuals is inconsistent. [, Vogiatzi MG, Jacobson-Dickman E, DeBoer MD. The British Journal of Psychiatry 2013;202:100-7. Circulation 2013;128:2517-31. Nutr Rev 2019;77:890-902. Vitamin D deficiency is associated with vascular dysfunction, arterial stiffening, left ventricular hypertrophy, and hyperlipidemia [119]. [, Sempos CT, Binkley N. 25-hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis. Horm Metab Res 2019;51:11-21. Vitamin D status in the United States remained stable in the decade between 20032004 and 20132014. Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 20152016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 219 years [39]. [, Caan B, Neuhouser M, Aragaki A, Lewis CB, Jackson R, LeBoff MS, et al. Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: New findings from an updated meta-analysis. Summary. [, Shahvazi S, Soltani S, Ahmadi SM, de Souza RJ, Salehi-Abargouei A. However, women with vitamin D intakes higher than 15 mcg (600 IU)/day at the start of the trial and who received the supplements experienced a 28% increased risk of invasive (but not in situ) breast cancer. JAMA 2017;317:1217-8. Calcium plus vitamin D supplementation and the risk of colorectal cancer. Identification and systematic appraisal. Int J Obes (Lond) 2012;36:387-96. A dose-response analysis found that each 20 nmol/L [8 ng/mL] increase in 25(OH)D was associated with a 9% lower risk of both all-cause and prostate cancer-specific mortality. There are two forms of vitamin D in the diet and supplements: Vitamin D2 (ergocalciferol):found in some. Four percent had levels higher than 125 nmol/L (50 ng/mL). The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. Diets low in vitamin D are more common in people who have milk allergy or lactose intolerance and those who consume an ovo-vegetarian or vegan diet [1]. Obesity does not affect the skins capacity to synthesize vitamin D. However, greater amounts of subcutaneous fat sequester more of the vitamin [1]. Rickets occurred mainly in Black children who were breastfed longer, were born with low birthweight, weighed less, and were shorter than other children. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. The fortification of milk (a good source of calcium) and other staples, such as breakfast cereals and margarine, with vitamin D beginning in the 1930s along with the use of cod liver oil made rickets rare in the United States [28,50]. J Nutr 2014;144:654-9. This video is all about new range of the moms co vitamin c range products I have reviewed and explained the benefits I hope you all wil. Ann Intern Med 2017;166:155-6. Am J Clin Nutr 2017;105:810-9. Sunscreens with an SPF of 8 or more appear to block vitamin D-producing UV rays. The emerging issue of 25-hydroxyvitamin D in foods. The impact of this form on vitamin D status is an emerging area of research. Gratuit Vitamin C Wikipedia Vitamin C, also known as ascorbi. Vitamin D toxicity has been caused by consumption of dietary supplements that contained excessive vitamin D amounts because of manufacturing errors, that were taken inappropriately or in excessive amounts, or that were incorrectly prescribed by physicians, [155-157]. One meta-analysis of 20 clinical trials compared the effects of 0.5 mcg (20 IU)/day to 1,250 mcg (50,000 IU)/week vitamin D supplementation for 26 months with those of placebo on glycemic control in 2,703 adults from around the world who had diabetes [143]. J Natl Cancer Inst 2007;100:1581-91. Vitamin D supplements may interact with several types of medications. The results showed no significant differences in rates of progression to type 2 diabetes; in serum glucose, insulin, or hemoglobin A1c levels; or in measures of insulin resistance. Few foods naturally contain vitamin D. The flesh of fatty fish (such as trout, salmon, tuna, and mackerel) and fish liver oils are among the best sources [17,1]. Plant milk alternatives (such as beverages made from soy, almond, or oats) are often fortified with similar amounts of vitamin D to those in fortified cow's milk (about 3 mcg [120 IU]/cup); the Nutrition Facts label lists the actual amount [24]. [. J Natl Cancer Inst 2019;111:158-69. Souhrnn se tak oznauj t jako kalciferoly. According to the United States Department of Agriculture (USDA) Food Composition Database, one 3.5-ounce (100-gram) serving of farmed Atlantic salmon contains 526 IU of vitamin D, or 66% of the. [, Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG. [, Laurent MR, Gielen E, Pauwels S, Vanderschueren D, Bouillon R. Hypervitaminosis D associated with tanning bed use: A case report. Studies have shown that vitamin D benefits bone health when taken in doses of 800-5,000 international units per day. All adults should consume recommended amounts of vitamin D and calcium from foods and supplements if needed. N Engl J Med 2019;381:520-30. Other meta-analyses of prospective studies have found associations between lower vitamin D status measured by serum 25(OH)D levels or vitamin D intakes and an increased risk of ischemic stroke, ischemic heart disease, myocardial infarction, and early death [122,123]. [, Keum N, Lee DH, Greenwood DC, Manson JE, Giovannucci E. Vitamin D supplementation and total cancer incidence and mortality: A meta-analysis of randomized controlled trials. [, Yetley EA. SHARE. [, Skversky AL, Kumar J, Abramowitz MK, Kaskel FJ, Melamed ML. For men with prostate cancer, whether vitamin D supplementation lengthens cancer-related survival is not clear. It is also a fat-soluble vitamin. CMAJ 2019;191:E390-4. JAMA Intern Med 2015;175:745-54. Thiazide diuretics (e.g., Hygroton, Lozol, and Microzide) decrease urinary calcium excretion. J Clin Endocrinol Metab 2016;101:1647-55. Effect of long-term vitamin D3 supplementation vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: A randomized clinical trial. Nutrients 2018, 10, 59; doi:10.3390/nu10010059. Individuals who have difficulty absorbing dietary fat might therefore require vitamin D supplementation [63]. Overall, clinical trials show that vitamin D supplementation does not reduce CVD risk, even for people with low 25(OH)D status (below 20 nmol/L [12 ng/mL]) at baseline [93,124]. Nutrients 2018 Apr 16;10(4). Multiple sclerosis Of course, as I state elsewhere on the site, it is somewhat of a disservice to discuss one nutrient alone and not discuss the vast array of nutrients required and the complex systems in Both forms are well absorbed in the small intestine. US Preventive Services Task Force recommendation statement. No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). Effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: A systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2019;28:900-8. However, comparing vitamin D intakes to serum 25(OH)D levels is problematic. Other dairy products made from milk, such as cheese and ice cream, are not usually fortified in the United States or Canada. A person can also boost . However, 18% were at risk of inadequacy (levels of 3049 nmol/L [1219.6 ng/mL]), and 5% were at risk of deficiency (levels below 30 nmol/L [12 ng/mL]). Interventions to prevent falls in community-dwelling older adults. Vitamin D is essential for healthy bones and teeth. [, Galior K, Grebe S, Singh R. Development of vitamin D toxicity from overcorrection of vitamin D deficiency: A review of case reports. Vitamin D has other roles in the body, including reduction of inflammation as well as modulation of such processes as cell growth, neuromuscular and immune function, and glucose metabolism [1-3]. Lancet 2014;383:1665-76. Fortified foods provide most of the vitamin D in American diets [1,22]. A large case-control study included 5,706 individuals who developed colorectal cancer and whose 25(OH)D levels were assessed a median of 5.5 years from blood draw to cancer diagnosis and 7,105 matched controls [101]. Cancer Epidemiol Biomarkers Prev 2014;23:1484-93. Clinical trial evidence provides some support for the observational findings. Recommended Dietary Allowance (RDA): Average daily level of intake sufficient to meet the nutrient requirements of nearly all (97%98%) healthy individuals; often used to plan nutritionally adequate diets for individuals. Ann Oncol 2018;29:1468-75. In addition, the Food and Drug Administration (FDA) has approved UV-treated mushroom powder as a food additive for use as a source of vitamin D2 in food products [18]. [, Li X, Liu Y, Zheng Y, Wang P, Zhang Y. More than 53 million adults in the United States have or are at risk of developing osteoporosis, which is characterized by low bone mass and structural deterioration of bone tissue that increases bone fragility and the risk of bone fractures [72]. Pediatrics 2008;122:1142-52. Here are my top 8 foods rich in vitamin D to start adding into your regimen: 1. Search for: Menu. [, Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Krstic G, Wetterslev J, Gluud C. Vitamin D supplementation for prevention of cancer in adults. [, O'Brien KM, Sandler DP, Taylor JA, Weinberg CR. Interventions to prevent falls in older adults: Updated evidence report and systematic review for the US Preventive Services Task Force. Hypercalcaemia following vitamin D and thiazide therapy in the elderly. JAMA 2017;317:2448-50. US Preventive Services Task Force recommendation statement. [, McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, et al. Vitamin D is a fat-soluble vitamin produced by our body when our skin is exposed to ultraviolet rays from sunlight. A variety of foods and their vitamin D levels per serving are listed in Table 3. Vitamin D is an important nutrient that aids a variety of functions in people of all ages, including bone health and metabolism. For a reader-friendly overview of Vitamin D, see our consumer fact sheet on Vitamin D. For information on vitamin D and COVID-19, see Dietary Supplements in the Time of COVID-19. Circulating vitamin D concentrations and risk of breast and prostate cancer: A Mendelian randomization study. MS is an autoimmune disease of the central nervous system that damages the myelin sheath surrounding and protecting nerve cells in the brain and spinal cord. Vitamin D sufficiency prevents rickets in children and osteomalacia in adults. A reverse J-shaped association between serum 25-hydroxyvitamin D and cardiovascular disease mortality: The CopD study. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. Am J Clin Nutr 2017;105:1372-81. [, Guirguis-Blake JM, Michael YL, Perdue LA, Coppola EL, Beil TL. Vitamin D status and supplementation before and after bariatric surgery: A comprehensive literature review. The vitamin D supplements were associated with serum 25(OH)D levels of 54 to 135 nmol/L (21.6 to 54 ng/mL). After reviewing data on vitamin D needs, an expert committee of the Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine (NASEM) concluded that people are at risk of vitamin D deficiency at serum 25(OH)D concentrations less than 30 nmol/L (12 ng/mL; see Table 1 for definitions of "deficiency" and "inadequacy") [1]. Elsevier, 2018. Clinical trials, however, do not support these findings. The FNB recommended avoiding serum 25(OH)D levels above approximately 125150 nmol/L (5060 ng/mL), and it found that even lower serum levels (approximately 75120 nmol/L [3048 ng/mL]) are associated with increases in rates of all-cause mortality, risk of cancer at some sites (e.g., pancreas), risk of cardiovascular events, and number of falls and fractures among older adults. Picciano MF. In addition to having an increased risk of vitamin D deficiency, people with these conditions might not eat certain foods, such as dairy products (many of which are fortified with vitamin D), or eat only small amounts of these foods. In addition to bone deformities and pain, severe rickets can cause failure to thrive, developmental delay, hypocalcemic seizures, tetanic spasms, cardiomyopathy, and dental abnormalities [45,46]. They use only USP ascorbic acid to produce their vitamin C products so you can be assured that you are getting the highest quality available. The concurrent presence of fat in the gut enhances vitamin D absorption, but some vitamin D is absorbed even without dietary fat. Facebook. Vitamin D in foods: An evolution of knowledge. Observational studies have linked lower serum 25(OH)D levels to an increased risk of diabetes, but their results might have been confounded by the fact that many participants were overweight or had obesity and were therefore more predisposed to developing diabetes and having lower 25(OH)D levels [1]. [, Durup D, Jorgensen HL, Christensen J, Tjonnland A, Olsen A, Halkjaer J, et al. Calcium plus vitamin D supplementation and the risk of breast cancer. Another study included 2,259 healthy individuals aged 45 to 75 years who had had one or more serrated polyps (precursor lesions to colorectal cancer) that had been removed [102]. [, Jorde R, Grimnes G. Vitamin D: No cure for depression. [, Song Z-y, Yao Q, Zhuo Z, Ma Z, Chen G. Circulating vitamin D level and mortality in prostate cancer patients: A dose-response meta-analysis. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press, 2010. Vitamin D and cardiovascular disease: Controversy unresolved. It may even help prevent cancer and protect against. J Midwifery Womens Health 2019;64:276-88. Vitamin D toxicity, otherwise known as hypervitaminosis D, can result in dehydration, fatigue, muscle weakness, vomiting, and calcification of tissues (68, 69). Join the ODS Email List. Pediatrics 2020;145:e20193574. Hazards of treating osteoporosis and hypertension concurrently with calcium, vitamin D, and distal diuretics. Am J Clin Nutr 2016;104:1151-9. The fifty bottles of 1000 IU vitamin D pills mentioned above would weigh in the ballpark of 2500 g. A typical vitamin D tablet weighs 150 mg and is >99.9% filling. Prolonged exclusive breastfeeding without vitamin D supplementation can cause rickets in infants, and, in the United States, rickets is most common among breastfed Black infants and children [47]. Possible explanations for this increase include genetic differences in vitamin D metabolism, dietary preferences, and behaviors that lead to less sun exposure [45,46]. The 'sunshine vitamin': benefits beyond bone? Colorectal cancer For example, a meta-analysis included 34 observational studies that followed 180,667 participants (mean age greater than 50 years) for 1.3 to more than 32 years. Few people near the equator develop the disease, whereas the prevalence is higher further north and south. Vitamin D: moving forward to address emerging science. [, Perez-Castrillon JL, Vega G, Abad L, Sanz A, Chaves J, Hernandez G, Duenas A. Vitamin D supplementation reduced cancer mortality rates by 13%, and most of the benefit occurred with daily supplementation. Scientific Reports 2020;10:7736. Talk with your doctor or nurse about vitamin D at your child's next check-up if you have questions. Vitamin D assays and the definition of hypovitaminosis D. Results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol 2018;84:2194-207. Vitamin D, calcium, and cancer: Approaching daylight? Assessing the vitamin D status of the US population. [, Elder CJ, Bishop NJ. [, Muller DC, Hodge AM, Fanidi A, Albanes D, Mai XM, Shu XO, et al. In the VITAL trial described above, 16,657 men and women 50 years of age and older with no history of depression and 1,696 with an increased risk of recurrent depression (that had not been medically treated for the past 2 years) were randomized to take 50 mcg (2,000 IU)/day vitamin D3 (with or without fish oil) or a placebo for a median of 5.3 years [135]. The human body produces vitamin D as a response to sun exposure. Cancer Res 2019;79:274-85. A randomized controlled trial of vitamin D3 supplementation in African American women. Hypercalcemia, in turn, can lead to nausea, vomiting, muscle weakness, neuropsychiatric disturbances, pain, loss of appetite, dehydration, polyuria, excessive thirst, and kidney stones. The FNB established ULs for vitamin D in 2010 (Table 4) [1]. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the Vitamin D Assessment Study: A randomized clinical trial. [, McNamara M, Rosenberger KD. Nutrients 2020; 12, 2237; doi:10.3390/nu12082237. Rates of deficiency varied by race and ethnicity: 17.5% of non-Hispanic Blacks were at risk of vitamin D deficiency, as were 7.6% of non-Hispanic Asians, 5.9% of Hispanics, and 2.1% of non-Hispanic White people. Vitamin D is a pro-hormone. [, Gotfredsen A, Westergren Hendel H, Andersen T. Influence of orlistat on bone turnover and body composition. Cochrane Database of Systematic Reviews 2018, issue 9, Art. In contrast, another meta-analysis of 30 clinical trials in 4,744 participants (mean age 54.5 years) that administered 5 mcg (200 IU) to 300 mcg (12,000 IU)/day vitamin D3 for a mean of 5.6 months showed that more than 20 mcg (800 IU)/day significantly reduced systolic and diastolic blood pressure in normal-weight participants who had hypertension [128]. Vitamin D3 is produced by sunlight on the skin. Effects of vitamin D supplementation on musculoskeletal health: A systematic review, meta-analysis, and trial sequential analysis. Pediatrics 2003;112:e132-5. The second trial included 155 adults aged 6080 years who had clinically relevant depressive symptoms, no major depressive disorder, and serum 25(OH)D levels less than 50 to 70 nmol/L (20 to 28 ng/mL) depending on the season; in addition, they were not taking antidepressants [133,134]. The incidence rate of rickets in the infants and children (younger than 7) seen by 2,325 pediatricians throughout Canada was 2.9 per 100,000 in 20022004, and almost all patients with rickets had been breastfed [49]. b Some fortified foods and beverages are included. Agency for Healthcare Research and Quality. Am J Clin Nutr 2019;110:150-7. Ann Oncol 2019;30:733-43. J Clin Endocrinol Metab 2016;101:394-415. All can be significantly helped with proper amounts of vitamin C. The factors that affect UV radiation exposure, individual responsiveness, and uncertainties about the amount of sun exposure needed to maintain adequate vitamin D levels make it difficult to provide guidelines on how much sun exposure is required for sufficient vitamin D synthesis [15,28]. Levels of 50 nmol/L (20 ng/mL) or more are sufficient for most people. Factors such as adiposity, skin pigmentation, vitamin D binding protein polymorphisms, and genetics contribute to differences in 25(OH)D levels between Black and White Americans. In contrast, a meta-analysis of 6 trials in 49,282 older adults found that daily vitamin D (10 or 20 mcg [400 IU or 800 IU]/day) and calcium (800 or 1,200 mg/day) supplementation for a mean of 5.9 years reduced the risk of any fracture by 6% and of hip fracture by 16% [81]. Am J Clin Nutr 2016;104:1039-51. AHRQ Publication No. Neurol Ther 2018;7:59-85. [. 2. Another study randomized 100 community-dwelling men and women aged 60 years and older (most were White) with serum 25(OH)D levels of 50 nmol/L (20 ng/ml) or less to 800 IU vitamin D3 or placebo for 1 year [86]. Whether vitamin D and incident fractures in community-dwelling individuals is inconsistent, Melamed ML, Y... Levels higher than 125 nmol/L ( 50 ng/mL ) or more are sufficient for most.... 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And cancer: A New drug interaction with an unexpected consequence of total fractures, or nonvertebral fractures compared... Risk: New findings from an updated meta-analysis A comprehensive literature review remained stable in the United or... Produce vitamin D supplementation on improving glucose homeostasis and preventing diabetes: A Mendelian study... A reverse J-shaped association between circulating 25-hydroxyvitamin D and thiazide therapy in the United States or.! And thiazide therapy in the decade between 20032004 and 20132014 moving forward to address emerging science T. of...

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